Amino Cd Quantum Dots
Product Description
Alfa Chemistry can provide customers with amino Cd quantum dots in the wavelength range of 450-665 nm. Cd-based quantum dots (QDs) coated with amino groups have unique optical properties, such as narrow emission, wide absorption and optical stability, and are widely used in photocatalysis, biological imaging, biosensors and other fields.
Applications
Biosensors
Pleskova et al. investigated the effect of quantum dots CdSe/ZnS-mercaptopropionic acid, (CdSe/CdZnS)ZnS-polyT and CdSeCdSZnS/polyT/SiO-NH2 on human erythrocytes. These nanomaterials greatly reduced the sedimentation rate of erythrocytes and altered the resistance of erythrocyte membranes to induced (acid and hypotonic) hemolysis. The morphology of erythrocytes after control and exposure to quantum dots was evaluated by atomic force microscopy, showing significant differences in the changes in the size and morphology of erythrocytes after exposure to the nanomaterials. Decreased hematocrit was the standard response for all QD types added to the blood. QD-NH2 showed maximum inhibition of ESR. QD caused displacement of the erythrocyte map and minimum displacement was recorded in the qd-polyt response. The kinetic criterion (acid hemolysis) was more sensitive than the integral parameter (low osmotic hemolysis) in evaluating the ameliorative effect of QD on erythrocyte membrane resistance.
Fig.1 Typical alteration of erythrocytes under the effect of QD-NH2; this QD type is characterized by emergence of stomatocytes and echinocytes as well. (Pleskova et al., 2014)
Optically Witchable Catalysts
Ukowski et al. reported the synthesis of a quantum dot (QD)-DNA covalent conjugate that can be used as an H2O2-free DNAase system with oxidase activity. Amino-coupled conjugation was performed between amino-modified oligonucleotides (CatG4-NH2) and carboxylated quantum dots (CdTe@COOH QDs). The obtained products were characterized by spectroscopic methods (UV-Vis, fluorescence, circular dichroism (CD) and IR) and transmission electron microscopy (TEM) techniques. A QD-DNA system with low polydispersity and high stability in aqueous solutions was successfully obtained. The catalytic activity of the QD-DNA conjugates was examined with visible light irradiation of the generated reactive oxygen species (ROS) using amperometric red and ABTS (2,2′-aminobis(3-ethylbenzothiazoline-6-sulfonate)) indicators. The synthetic QD-DNAase exhibited stronger catalytic activity compared to the reference system (a mixture of QDs and DNAase). This supports the hypothesis that the covalent linkage of the DNA enzyme to the QD surface has a favorable effect on its catalytic activity. The results demonstrate that the QD-DNAase system can be used to generate signals by light irradiation. The light-induced oxidase activity of the conjugate was demonstrated, demonstrating that the QD-DNAase system can be used to develop new cellular bioassays, such as for the determination of oxygen radical scavengers.
Fig.2 Transmission electron microscopy (TEM) images of nanoparticles: QDs (A); QD-DNA (B); QD/DNA mixture at a 1:3 molar ratio (C). (Ukowski et al., 2020)
Alfa Chemistry can provide a variety of complex and customized fluorescent quantum dot products. Our products involve a variety of fluorescent quantum dot products. Alfa Chemistry provides products with high fluorescence quantum yield, stable quality and relatively low price. Our products are constantly updated. If the product you need is not in our catalog, please feel free to contact us, we provide relevant custom services.
References
- Pleskova, et al. Interactions of Quantum Dots with Donor Blood Erythrocytes In Vitro[J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE C/C OF BIULLETEN' EKSPERIMENTAL'NOI BIOLOGII I MEDITSINY, 2014.
- Ukowski, K. , J. Kosman , and B. Juskowiak . Light-Induced Oxidase Activity of DNAzyme-Modified Quantum Dots[J]. International Journal of Molecular Sciences, 2020, 21(21):8190.
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