Oil Dispersible CuInS/ZnS Quantum Dots
Product Description
Alfa Chemistry offers CuInS/ZnS core/shell quantum dots with an emission range of 538 nm to 600 nm. These quantum dots consist of CuInS as the core and ZnS as the shell, with the QDs surface surrounded by hydrophobic groups. Alfa Chemistry offers quantum dots with strong lattice strength and stable performance. The internal pressure caused by the lattice defects of the quantum dots is effectively reduced, so the quantum dots have high luminescence efficiency and stability. Our CuInS/ZnS quantum dots can be used for high sensitivity cell imaging, photovoltaic devices, solar cells and light emitting devices.
Features
Our products have the characteristics of uniform particle size, broad absorption spectrum, symmetrical emission spectrum, high and stable fluorescence intensity.
Storage conditions
4°C sealed and protected from light.
Applications
Photothermal Nanodrugs
Posterior capsule opacification (PCO) following cataract surgery is one of the leading causes of visual impairment and blindness. The cause of PCO is cystic fibrosis of the implanted lens (IOLs) during the dedifferentiation of lens epithelial cells (LECs) that have undergone epithelial mesenchymal transition. Mao et al. demonstrated the use of carboxylated CuInS/ZnS quantum dots (ZCIS QDs) as photothermal nanodrugs that do not contain toxic heavy metals and are more biocompatible. ZCIS QDs were modified into the non-optical part of the IOL by facial activation-immersion method. Under mild near-infrared laser irradiation, ZCIS QDs-modified IOLs (QDs-IOLs) generate local heat and prevent the proliferation of LECs on the surface of QDs-IOLs. The results of Mao et al. provide experimental evidence for further combined application of nanotechnology and photothermal therapy in the clinical treatment of PCO.
Fig. 1 A. Schematic diagram for the synthesis of ZCIS QDs. B. TEM image of ZCIS QDs. (Mao et al., 2020)
Nanomedicines
Lv et al. demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" therapeutic nanodrugs with intrinsic imaging and therapeutic capabilities in a well-defined nanostructure.ZCIS QDs were used for multispectral optical tomography (MSOT) imaging and synergistic PTT/PDT therapy. Due to the inherent fluorescence/MSOT imaging capability of ZCIS QDs, their size distribution maps were successfully observed in vivo. Smaller nanodrugs (ZCIS NMs-25) had longer tumor retention time, higher tumor uptake and deeper tumor penetration than larger nanodrugs (ZCIS NMs-80). Lv et al. also explored the ability of QDs to mediate photo-induced tumor ablation. The results confirmed that the dazzling NMs have both intrinsic photothermal and photodynamic effects under a single 660 nm laser irradiation, resulting in high efficacy on tumors.
Fig. 2 In vitro cell experiments. Confocal fluorescence images showing in vitro penetration of ZCIS NMs-25 and ZCIS NMs-80 into 4T1 multicellular spheroids (MCSs). (Lv et al., 2016)
Alfa Chemistry can provide a variety of complex and customized core-shell fluorescent quantum dot products. Our products involve a variety of fluorescent quantum dot products. Alfa Chemistry provides products with high fluorescence quantum yield, stable quality and relatively low price. Our products are constantly updated. If the product you need is not in our catalog, please feel free to contact us, we provide relevant custom services.
References
- Mao, Y. , et al. CuInS/ZnS quantum dots modified intraocular lens for photothermal therapy of posterior capsule opacification[J]. Experimental Eye Research, 2020, 202(10):108282.
- Lv, G. , et al. Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines With Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy[J]. Acs Nano, 2016:acsnano.6b05419.
* It should be noted that our service is only used for research, not for clinical use.
