Water Dispersible CuInS/ZnS Quantum Dots
Product Description
Alfa Chemistry offers water dispersible CuInS/ZnS core/shell quantum dots in the emission range of 550 nm to 800 nm. Alfa Chemistry offers quantum dots with strong lattice strength and stable performance. The internal pressure caused by the lattice defects of the quantum dots is effectively reduced, so the quantum dots have high luminescence efficiency and stability. Our water dispersible CuInS/ZnS quantum dots quantum dots can be used for high sensitivity cell imaging, photovoltaic devices, solar cells and light emitting devices.
Features
Uniform particle size
Biocompatibility
High and stable fluorescence intensity
High quantum field
Applications
Fluorescent Probes
Glutathione-covered water-soluble CuInS/ZnS quantum dots (QDs) were prepared by a microwave-assisted method by Zhang et al. Their fluorescence has an excitation/emission peak at 380/570 nm and was found to be quenched by hydrogen peroxide (H2O2) produced by the catalytic oxidation of uric acid (UA) and oxygen by uricase. These findings were used for the determination of UA with a detection limit of 50 nM for UA, which is lower than its quantum dot, and a detection range of 0.25-4.0 μM. The assay is simple and sensitive and does not require further modifications to the QD.
Fig.1 TEM and high-resolution TEM (inset) images of GSH-capped CuInS core (a) and CuInS/ZnS QDs (b). (Zhang et al., 2018)
Gene Expression
Tsolekile et al. enhanced the bioactivity by conjugating water-soluble CuInS/ZnS QDs with 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin-photosensitizer. Glutathione-capped CuInS/ZnS QDs were prepared in aqueous medium using a kitchen pressure cooker, during which the ratios of Cu and In were adjusted differently (1:4 and 1:8) and at different temperatures (95 °C, 190 °C and 235 °C). Optical characterization showed that the synthesized CuInS/ZnS QDs became red-shifted after passivation compared to the core (CuInS) and emitted in the red region, while cytotoxicity studies showed good cell viability against normal kidney fibroblasts (BHK21). Highly fluorescent water-soluble QDs were conjugated to 5,10,15,20-tetra(3-hydroxyphenyl)porphyrin (mTHPP) by esterification reaction at room temperature. The results showed that the conjugates were highly cytotoxic to THP-1 cells compared to bare QDs and enhanced local uptake of the cells, which is promising as a cancer therapeutic agent.
Fig.2 TEM images and size distribution curves of CuInS QDs. (Tsolekile et al., 2020)
Targeted Imaging
Zhang et al. introduced a simple and sensitive fluorescence assay based on the internal filtration effect (IFE) for the determination of alkaline phosphatase (ALP) activity in serum and living cells. CuInS/ZnS quantum dots (CIS/ZnS QDs) and p-nitrophenyl phosphate (PNPP) were used as a fluorescent indicator and substrate, respectively, for the assessment of ALP activity. Since CIS/ZnS QDs have an effective excitation at 405 nm along with a large Stokes shift emission at 588 nm, the absorption peak of p-nitrophenyl phosphate (PNP) at 405 nm, a hydrolysis product of PNPP and ALP, can act as a competing absorber to absorb the excitation light of CIS/ZnS QDs, resulting in the CIS/ZnS QDs The excellent biocompatibility of CIS/ZnS QDs allows the sensor to monitor endogenous ALP in living cells.
Fig. 3 TEM image of CIS core (a) and CIS/ZnS QDs (b). (Zhang et al., 2018)
Alfa Chemistry can provide a variety of complex and customized fluorescent quantum dot products. Our products involve perovskites precursors, perovskites quantum dots, quantum dot kit, single layer quantum dots, upconverting nanoparticles and other fluorescent quantum dots. Alfa Chemistry provides products with high fluorescence quantum yield, stable quality and relatively low price. Our products are constantly updated. If the product you need is not in our catalog, please feel free to contact us, we provide relevant custom services.
References
- Zhang, F. , et al. Enzymatic determination of uric acid using water-soluble CuInS/ZnS quantum dots as a fluorescent probe[J]. Mikrochimica acta, 2018, 185(11).
- Tsolekile, N. , et al. Cytotoxicity, fluorescence tagging and gene-expression study of CuInS/ZnS QDS-meso (hydroxyphenyl) porphyrin conjugate against human monocytic leukemia cells[J]. Scientific Reports, 2020, 10(1).
- Zhang, et al. Rapid aqueous synthesis of CuInS/ZnS quantum dots as sensor probe for alkaline phosphatase detection and targeted imaging in cancer cells[J]. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2018.
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