Water Soluble Carbon dots
Product Description
Alfa Chemistry offers water soluble carbon dots at 410-570 nm with excellent optical properties, good water solubility, environmental friendliness, wide source of raw materials, low cost, and good biocompatibility. The suitable size, low cost and good biocompatibility of carbon dots have a wide range of applications for biomarkers and fluorescent probes.
Applications
Nanosensor
Based on the target-responsive aggregation of the carbon dot/cysteine system, a convenient fluorescent and light scattering dual-mode nanosensor for the detection of silver(I) ions was developed by Liu et al. The water-soluble fluorescent carbon dots (CDs) synthesized by a one-pot hydrothermal method exhibited an emission peak at 441 nm under excitation at 352 nm. The fluorescence of CDs was quenched by Ag+ via electron transfer, while the light scattering intensity of CDs was significantly enhanced, providing a dual-mode means for the detection of analyte Ag+. The relative fluorescence intensity was proportional to the Ag+ concentration between 0.1 μM and 265 μM with a detection limit of 50 nM. The new nanosensor is simple, fast and sensitive, and was applied to the detection of Ag+ in real water samples with satisfactory results. In addition, the current dual-mode sensor based on CDs provides a promising platform for environmental sensing applications.
Fig.1 Schematic illustration of CDs-based fluorometric (FL, a) and light-scattering (LS, b) dual-modal nanosensor for Ag+ detection. (Liu et al., 2017)
Biomarker Detection
Carbon dots (C-dots) exhibit strong absorption in the UV range, which is used to transfer energy from the N2 laser (337 nm) of matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) to the analyte for rapid detection. Due to this power and extremely small size (2-4 nm), they were used to enhance the signal intensity of MALDI-MS peaks of low molecular weight biomarkers in serum. Khan et al. used the extraordinary properties of C-dot as a substrate to detect 5-hydroxytryptamine (Sr), glutamate (GA) and dopamine hydrochloride (DA) by MALDI-MS. These chemicals are major bioindicators or biomarkers for the detection of dreaded diseases such as Alzheimer's disease. The detection limits for Sr, GA and DA were found to be 3, 5 and 8 nM, respectively. The use of C-dots can greatly reduce the background noise in MALDI-MS spectra because C-dots are superior to traditional substrates such as 2, 5-dihydroxybenzoic acid (DHB). The current method can be further applied to many other drugs or pharmaceutical compounds in the near future.
Fig. 2 (a) UV–Vis spectra of C-dots also showing photographs under normal light and UV light. (b) Showing the fluorescence of C-dots. (c) TEM image of purified C-dots. (Khan et al., 2015)
Alfa Chemistry can provide a variety of complex and customized fluorescent quantum dot products. Our products involve perovskites precursors, perovskites quantum dots, quantum dot kit, single layer quantum dots, upconverting nanoparticles and other fluorescent quantum dots. Alfa Chemistry provides products with high fluorescence quantum yield, stable quality and relatively low price. Our products are constantly updated. If the product you need is not in our catalog, please feel free to contact us, we provide relevant custom services.
References
- Liu, G. , et al. Dual-modal fluorescence and light-scattering sensor based on water-soluble carbon dots for silver ions detection[J]. Analytical Methods, 2017, 9.
- Khan, M. S. , et al. Exploring the ability of water soluble carbon dots as matrix for detecting neurological disorders using MALDI-TOF MS[J]. International Journal of Mass Spectrometry, 2015, 393:25-33.
* It should be noted that our service is only used for research, not for clinical use.
