Product Description
Water-soluble ZnSe/ZnS quantum dot products are core/shell type fluorescent nanomaterials with ZnSe as the core and ZnS as the shell layer, and the surface is wrapped by hydrophilic ligands, with an average quantum yield of 80%, and can provide customers with different grams of products around 410 nm-430 nm wavelength. The product has the characteristics of uniform particle size, broad absorption spectrum, symmetric emission spectrum, high and stable fluorescence intensity, etc.
About ZnSe/ZnS Quantum Dots
ZnSe quantum dots are a new type of environmentally friendly "green" semiconductor nanomaterial. As a wide band gap semiconductor material, ZnSe is an important material for the manufacture of blue-green wavelength semiconductor light-emitting devices. Alfa Chemistry provides ZnSe/ZnS quantum dots with excellent characteristics such as uniform size, strong monodispersity, high fluorescence quantum yield, good stability, etc. They can be used in blue semiconductor optoelectronic devices, solar cells, biomarkers and other fields.
Applications
Drug Carriers
Li et al. synthesized novel chitosan-ZnSe/ZnS (CS-ZnSe/ZnS) nanoparticles by a one-step ionic gel technique, using ZnSe/ZnS quantum dots (ZnSe/ZnS QDs) as a cross-linking agent and for fluorescent labeling. This method not only avoids the use of emulsifiers and chemical cross-linking agents, but also avoids the possibility of causing damage to the drug. The fluorescent CS-ZnSe/ZnS nanoparticles have a size of about 100-500 nm and are stable under physiological environment. Low cytotoxicity was ensured by the investigation of mouse lung cancer cells. When the concentration of CS-ZnSe/ZnS nanoparticles was increased to 200 μg·mL-1, the cell survival rate remained 99%. In in vitro drug release experiments, 5-fluorouracil (5-Fu) loaded in CS-ZnSe/ZnS nanoparticles showed superior sustained release performance and longer equilibration time compared to pure 5-Fu. Fluorescent CS-ZnSe/ZnS nanoparticles are expected to be used for biofluorescent labeling and drug carriers.
Fig. 1 Schematic representation of the fabrication process of drug-loading fluorescent CS-ZnSe/ZnS nanoparticles. (Li, 2015)
Cellular Labeling
ZnSe/ZnS quantum dots have innumerable possibilities in biological research, including cellular labeling. Water-soluble QDs with strong blue emission were efficiently synthesized via the aqueous phase route. the synthesized QDs are approximately 5-6 nm and fluoresce blue-green under UV light. Reshma et al. used HepG2 cells to address the possible adverse effects of ZnSe/ZnS QDs in the liver system; HepG2 cells are routinely employed as a vitreous cell model. Also, the absorption, distribution, metabolism, excretion and toxicity (ADME and T) of ZnSe/ZnS were analyzed in mice, followed by intravenous (i.v) and intraperitoneal (i.p) injections at a dose of 10 mg/kg, and it was found that ZnSe/ZnS QDs did not exhibit any significant toxic results in mice.
Fig.2 Assessment of ZnSe/ZnS quantum dots on cell integration, toxicity and biodistribution in mice. (Reshma, 2020)
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References
- Li, et al. Synthesis and characterization of fluorescent chitosan - ZnSe/ZnS nanoparticles for potential drug carriers. RSC Advances, 2015, 5, 49:38810-38817.
- Reshma, V. , et al. Water dispersible ZnSe/ZnS quantum dots: Assessment of cellular integration, toxicity and bio-distribution. 2020.
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